Random error with User Profile Service Application remedied by reboot

Some of my servers are running into an intermittent problem. Every so often, the User Profile Service Application is not accessible. A reboot seems to fix the issue, but I don't know why and haven't found anything conclusive out there. Here's what I am seeing in the ULS logs:


User Profile Application Proxy failed to retrieve partitions from User Profile Application: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_PartitionIDs()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.IsAvailable(SPServiceContext serviceContext) a99603f0-3dc1-4312-af7a-5e2240082814
User Profile Application Proxy failed to retrieve partitions from User Profile Application: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_PartitionIDs()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.IsAvailable(SPServiceContext serviceContext) a99603f0-3dc1-4312-af7a-5e2240082814
User Profile Application Proxy failed to retrieve partitions from User Profile Application: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_PartitionIDs()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.IsAvailable(SPServiceContext serviceContext) a99603f0-3dc1-4312-af7a-5e2240082814
User Profile Application Proxy failed to retrieve partitions from User Profile Application: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_PartitionIDs()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.IsAvailable(SPServiceContext serviceContext) a99603f0-3dc1-4312-af7a-5e2240082814
User Profile Application Proxy failed to retrieve partitions from User Profile Application: Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_PartitionIDs()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.IsAvailable(SPServiceContext serviceContext) a99603f0-3dc1-4312-af7a-5e2240082814






Microsoft.Office.Server.UserProfiles.UserProfileApplicationNotAvailableException: No User Profile Application available to service the request. Contact your farm administrator.    at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.get_ApplicationProperties()
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.CheckAdministrationAccess(UserProfileApplicationAdminRights rights, Boolean requireAllRights)
     at Microsoft.Office.Server.Administration.UserProfileApplicationProxy.CheckAdministrationAccess(UserProfileApplicationAdminRights rights)
     at Microsoft.Office.Server.UserProfiles.ProfileManagerBase.CanManagePeople(UserProfileApplicationProxy userProfileApplicationProxy)
     at Microsoft.Office.Server.UserProfiles.ProfileManagerBase.get_IsProfileAdmin()
     at Microsoft.Office.Server.UserProfiles.UserProfileManager..ctor(SPServiceContext serviceContext, Boolean IgnoreUserPrivacy, Boolean backwardCompatible)
     at Microsoft.Office.Server.UserProfiles.UserProfileManager..ctor(SPServiceContext serviceContext, Boolean IgnoreUserPrivacy)
     at NewsGator.Social.Library.Users.CachingUserProfileManager.<>c__DisplayClass10.<GetCachedInstance>b__f()
     at NewsGator.Social.Library.Caching.NGCache.RetrieveAndCache[T](String cacheKey, TimeSpan ts, Func`1 dataLoader)
     at NewsGator.Social.Library.Users.CachingUserProfileManager.GetCachedInstance(Boolean ignorePrivacy)
     at NewsGator.Social.Library.UserManager..ctor()
     at NewsGator.Social.Web.ClientRuntime.RegisterPageScripts(Page page, ScriptManager scriptManager)
     at NewsGator.Social.Web.CommunitiesOverviewWebPart.CreateChildControls()
     at System.Web.UI.Control.EnsureChildControls()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Control.PreRenderRecursiveInternal()
     at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint) a99603f0-3dc1-4312-af7a-5e2240082814






Exception occured while connecting to WCF endpoint: System.ServiceModel.CommunicationException: Could not connect to http://[hostname removed]:32843/06721706d40049bf9fe12b94be8f1912/ProfilePropertyService.svc. TCP error code 10048: Only one usage of each socket address (protocol/network address/port) is normally permitted [ip address removed]:32843.
  ---> System.Net.WebException: Unable to connect to the remote server
 ---> System.Net.Sockets.SocketException: Only one usage of each socket address (protocol/network address/port) is normally permitted [ip address removed]:32843
     at System.Net.Sockets.Socket.DoConnect(EndPoint endPointSnapshot, SocketAddress socketAddress)
     at System.Net.ServicePoint.ConnectSocketInternal(Boolean connectFailure, Socket s4, Socket s6, Socket& socket, IPAddress& address, ConnectSocketState state, IAsyncResult asyncResult, Int32 timeout, Exception& exception)
     --- End of inner exception stack trace ---
     at System.Net.HttpWebRequest.GetRequestStream(TransportContext& context)
     at System.Net.HttpWebRequest.GetRequestStream()
     at System.ServiceModel.Channels.HttpOutput.WebRequestHttpOutput.GetOutputStream()
     --- End of inner exception stack trace ---
    Server stack trace: 
     at System.ServiceModel.Channels.HttpOutput.WebRequestHttpOutput.GetOutputStream()
     at System.ServiceModel.Channels.HttpOutput.Send(TimeSpan timeout)
     at System.ServiceModel.Channels.HttpChannelFactory.HttpRequestChannel.HttpChannelRequest.SendRequest(Message message, TimeSpan timeout)
     at System.ServiceModel.Channels.RequestChannel.Request(Message message, TimeSpan timeout)
     at System.ServiceModel.Channels.SecurityChannelFactory`1.SecurityRequestChannel.Request(Message message, TimeSpan timeout)
     at System.ServiceModel.Dispatcher.RequestChannelBinder.Request(Message message, TimeSpan timeout)
     at System.ServiceModel.Channels.ServiceChannel.Call(String action, Boolean oneway, ProxyOperationRuntime operation, Object[] ins, Object[] outs, TimeSpan timeout)
     at System.ServiceModel.Channels.ServiceChannelProxy.InvokeService(IMethodCallMessage methodCall, ProxyOperationRuntime operation)
     at System.ServiceModel.Channels.ServiceChannelProxy.Invoke(IMessage message)    Exception rethrown at [0]: 
     at System.Runtime.Remoting.Proxies.RealProxy.HandleReturnMessage(IMessage reqMsg, IMessage retMsg)
     at System.Runtime.Remoting.Proxies.RealProxyPrivateInvoke(MessageData& msgData, Int32 type)
     at Microsoft.Office.Server.UserProfiles.IProfilePropertyService.GetProfileProperties()
     at Microsoft.Office.Server.UserProfiles.ProfilePropertyServiceClient.<>c__DisplayClass1.<GetProfileProperties>b__0(IProfilePropertyService channel)
     at Microsoft.Office.Server.UserProfiles.MossClientBase`1.ExecuteOnChannel(String operationName, CodeBlock codeBlock)
     at Microsoft.Office.Server.UserProfiles.ProfilePropertyServiceClient.ExecuteOnChannel(String operationName, CodeBlock codeBlock)